Production of Ribotides of 4-Hydroxy- and 4-Aminopyrazolo [3, 4-d] pyrimidine by Brevibacterium ammoniagenes
نویسندگان
چکیده
منابع مشابه
Studies on 4-aminopyrazolo(3, 4-d)pyrimidine: growth inhibition and relief in Neurospora crassa.
An analogue of adenine, 4-aminopyrazolo(3,4d)pyrimidine (4-APP), has recently been shown to be a potential antineoplastic agent. Skipper, Robins, and Thomson (1955) demonstrated that the growth of an adenocarcinoma and two leukemias of the mouse was inhibited or retarded by the administration of 4-APP. Hsu, Robins and Cheng (1956) showed that 4-aminopyrazolo(3,4d)pyrimidine exerts differential ...
متن کاملSynthesis and Biological Evaluation of 4-hydroxychromenyl arylmethyl-6-hydroxy pyrimidine-2, 4-dione Derivatives
Background: An efficient, promoted tri-component catalytic reaction between barbituric acid (or N,N-dimethyl barbituric acid), 4-hydroxy coumarin, and a wide range of aryl aldehydes using zinc oxide nanowires (ZnO NWs) to obtain some new 4-hydroxychromenylarylmethyl-6-hydroxypyrimidine-2,4-diones is described. Method: The reactants were successfully condensed ...
متن کاملEffects of 4-aminopyrazolo (3,4-d)pyrimidine and 1-methyl-4-aminopyrazolo(3,4-d)pyrimidine on nucleic acid purine metabolism in ascites tumors.
The effect of a single injection of a therapeutic level of either 4-aminopyrazÃ3lo(3,4rf)pyrimidine or l-methyl-4-aminopyrazolo(3,4-¿)pyrimidine on the incorporation of glycine-C14, adenine-C14, or guanine-C14 into RNA and DNA adenine and guanine during the 12-hour period after drug administration has been studied in the Ehrlich ascites carcinoma, which is sensitive to both drugs, and in Sarco...
متن کاملThe metabolism of 4-aminopyrazolo(3,4-d)pyrimidine in normal and neoplastic tissues.
several normal and neoplastic mouse tissues. APP is rapidly cleared from the peritoneal fluid and blood after intraperitoneal or intravenous administration. The drug is taken up by the blood cells and is lost from them less rapidly than from serum. Approximately one-half of the administered drug is excreted in the urine from nor mal mice in 24 hours, and one-half of this is within the 1st hour....
متن کاملSynthesis, Radioiodination and Biodistribution Evaluation of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxybenzofuran-6-ol
This study describes the organic synthesis of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxy benzofuran-6-ol (SPBF) as an example of a benzofuran derivative used as a new series of amyloid imaging agents. These benzofuran derivatives may be useful amyloid imaging agents for detecting B-amyloid plagues in the brain of Alzheimer’s disease. The precursor is 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1972
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.36.1405